The groundbreaking findings from the Human Microbiome Project revealed that there are hundreds of species of microbes on human skin. The majority of these microbes don't live anywhere else in the world, and this knowledge has helped us begin to understand the mutual relationship between humans and microbes. It’s now clear that you need your skin microbiome to optimize skin health, fundamentally changing skin care forever. We’ll discuss the critical role of microbiome diversity and the transformative impact of DNA sequencing technology. We’ll learn how modern chemical interventions affect the skin microbiome and how innovative approaches to skincare are being developed to optimize long-term skin health.